IV Symposium

Glia Diversity in Neuromodulation
and Neurodegeneration

May 29, 2019 - FFULisboa

Satellite event of the
XVI Meeting of the Portuguese Society for Neuroscience

The Portuguese Glial Network invites you to attend and participate at the IV Symposium of the Portuguese Glial Network on May 29th, 2019. The Symposium will be held at the Faculty of Pharmacy of the University of Lisbon (FFULisboa).

This Glial meeting will focus on indirect and direct conversion of somatic cells into neural cells to model diseases of the central nervous system (CNS), and on new evidences about the specific roles of different glial cell types, their regional diversity, and contribution to disease onset, progression and neurodegeneration. Emphasis will be given in how glial cells and neurons are intermingled and mutually depend on each other to maintan CNS homeostasis. The Symposium will provide forward looking activities where students will have the opportunity to interact, share and discuss their research data, as well as receive constructive feedback from scientists and leaders in the field.

Laurent Roybon
Lund University,
Sweden

"Can induced pluripotent stem cells help us decipher the role of glial cells in Parkinson’s disease?"

Kathrin Meyer
Ohio State University,
USA

"Astrocyte in vitro models for neurological and neurodegenerative disorders"

Tarja Malm
University of Eastern Finland,
Finland

"Modeling microglial dysfunctions in AD"

Tanja Kuhlmann
University Hospital Münster,
Germany

"How to wrap the myelin: New approaches to understand myelin diseases"

Scientific Program

09:30-10:00 REGISTRATION

10:00 WELCOME
Dora Brites (iMed.ULIsboa, University of Lisbon, Portugal)

10:15 PLENARY LECTURE | ROCHE - "Can induced pluripotent stem cells help us decipher the role of glial cells in Parkinson’s disease?"
Laurent Roybon (Lund University, Sweden)

11:00 COFFEE BREAK

11:30-13:00 | SESSION I – ASTROCYTES: BIOLOGY AND PATHOLOGY
Chair: João Oliveira (ICVS, University of Minho, Portugal)

11:30 “Skin derived astrocytes as a tool to study disease severity and drug responsiveness”
Invited Speaker: Kathrin Meyer (The Ohio State University, US)
12:00 “Unravelling NLRP3 inflammasome expression in astrocytes”
        Claudia Valente (IMM, University of Lisbon, PT)
12:20 “Astrocyte phenotypic aberrancy differs from the spinal cord to the cortical brain in ALS disease”
        Ana Rita Vaz (iMed.ULisboa, University of Lisbon, PT)
12:40 “The role of astrocytic calcium signaling in the cognitive function”
        Sónia Guerra-Gomes (ICVS School of Medicine, University of Minho, PT)
12:50 “Microglial and astrocytic pathology in a mouse model of Machado-Joseph disease”
        Ana Bela Campos (ICVS School of Medicine, University of Minho, PT)

13:00-14:00 – LUNCH

14:00:15:30 | SESSION II – MICROGLIA ACTIVATION AND IMMUNOREGULATION
Chair: Francisco Ambrósio (CNC.IBILI Consortium, University of Coimbra, Portugal)

14:00 “Modeling microglial dysfunctions in AD”
Invited Speaker: Tarja Malm (University of Eastern Finland, FI)
14:30 “Controlling microglia-mediated neuroinflammation in retinal diseases: role of adenosine A2A receptors”
        Raquel Santiago (CIBB, University of Coimbra, PT)
14:50 "Emerging roles of glial Striatal-Enriched Protein Tyrosine Phosphatase (STEP)"
        Graça Baltazar (CICS, University of Beira Interior, PT)
15:10 “TNF and glutamate dependent microglia reactivity under a psychoactive drug”
        Teresa Summavielle (i3S/IBMC, University of Porto, PT)
15:20 “IL-4 skews the microglial developmental program during cerebellar maturation”
        Joana Guedes (CIBB, University of Coimbra, PT)

15:30:17:00 | SESSION III - NETWORK WITH SCIENTISTS AND INTERACTIVE POSTER SESSION
This session, besides allowing poster viewing, features discussion groups that are led by moderators who ensure focused conversations around the key issues listed in each selected poster by session topic. Attendees should bring their printed A4 poster copies and informal setting will facilitate sharing of ideas and active networking.
(With coffee and drinks, Library of the Faculty of Pharmacy)

Poster viewing

15:30 – 16:00
Presenting authors are kindly requested to be near their posters for informal discussion

Table 1 – Astrocytes

Discussion Leaders:
João Oliveira and Graça Baltazar

16:00 Ana Bernardo, CIBB, UCoimbra
16:15 Cátia Gomes, iMed.ULisboa
16:30 Joana Gomes, IMM, ULisboa

Table 2 – Microglia

Discussion Leaders:
Francisco Ambrósio and Tarja Malm

16:00 Gonçalo Garcia, iMed.ULisboa
16:15 Illyane Lima, CEDOC-NMS
16:30 Camila Cabral, IBMC/i3S, UPorto

Table 3 – Oligodendrocytes

Discussion Leaders:
Ana Seixas and Tanja Kuhlmann

16:00 Joana Mateus, iMM, ULisboa
16:15 Catarina Barros, iMed.ULisboa
16:30 Rita Soares, IMM, ULisboa

Table 4 – Glial-neuronal interactions

Discussion Leaders:
Laurent Roybon and Ana Rita Vaz

16:00 Haissa de Castro, U. Lausanne
16:15 Pedro Dionísio, iMed.ULisboa
16:30 Catarina Sequeira, iMed.ULisboa

Table 5 – Mixed topics

Discussion Leaders:
Adelaide Fernandes and João Relvas

16:00 Diana Nascimento, ICVS, UMinho
16:15 Andreia Pinho, ICVS, UMinho
16:30 Inês Aires, CIBB, UCoimbra

17:00-18:00 | SESSION IV – OLIGODENDROCYTES: MYELIN DYSFUNCTION AND RENEWAL
Chair: João Relvas (i3S/IBMC, University of Porto, Portugal)

17:00 “Actin dynamics and mechanisms of regulation in oligodendrocyte biology”
Ana Seixas (i3S/IBMC, University of Porto, PT)
17:20 “The paradigm shift on remyelination failure problem – do mechanical properties play a crucial role?”
Eva Carvalho (i3S/IBMC, University of Porto, PT)
17:30 “How to wrap the myelin: New approaches to understand myelin diseases”
Invited Speaker: Tanja Kuhlmann (Neuropathology, University of Munster, DE)

18:00 | CLOSING